Academy
Advances in Immunohematology: bridging serology, molecular science and clinical practice
Nidhi Mehta
Priti Desai
Anisha Navkudkar
From complex antibody puzzles to rare blood group logistics, the ISBT Academy Session on Advances in Immunohematology brought together experts and learners in a dynamic exploration of modern transfusion challenges.
Immunohematology is no longer confined to the test tube. It lives at the intersection of laboratory precision, molecular genetics, and urgent clinical decision making. The ISBT Academy Session on Advances in Immunohematology reflected this evolution, assembling Transfusion Medicine Specialists, clinicians, immunohematologists, laboratory professionals, and residents for a focused scientific exchange.
The programme was carefully designed to connect serological foundations with contemporary molecular practice, with particular emphasis on pediatric transfusion, hemolytic disease of the fetus and newborn (HDFN), and the management of rare blood groups.
Satyam Arora discussing alloimmunisation mechanisms and transfusion strategies in pediatric thalassemia.
The program proceeded with complex case presentations by Mingmar Sherpa, showcasing unique scenarios with significant clinical implications and reinforcing the importance of multidisciplinary collaboration.
Interactive case discussion session engaging participants in antibody identification challenges
The role of molecular techniques was further explored by Amit Shreshta in Red Cell Genotyping: How Do We Implement It? This talk addressed the transition from conventional serology to genotyping, including indications, workflow integration, cost considerations, and clinical impact. It highlighted a strong interest in implementation strategies, particularly for managing multiply transfused patients and those with complex antibody profiles.
Interactive case discussion session engaging participants in antibody identification challenges
Presentation on integrating red cell genotyping into routine transfusion practice.
A highly interactive dry workshop and discussion session focused on navigating complex transfusion scenarios was conducted by Shamee Shastry, Satyam Arora and Aikaj Jindal. Using case simulations, participants worked through challenging antibody identification problems, transfusion decision-making in urgent settings, and communication between laboratory and clinical teams. Feedback indicated that this format was one of the most valuable components of the program, reinforcing learning through peer discussion and expert moderation.
Faculty moderating the hands-on immunohematology workshop session.
Several sessions highlighted the growing importance of rare blood group management. The presentations provided an overview of regional initiatives, donor recruitment strategies, and cross-border collaboration. The molecular perspective was further strengthened by Swati Kulkarni by her views on the molecular basis of rare blood group phenotypes in Indians, offering insights into population-specific variants and their relevance for transfusion practice. This was complemented by talks on intrauterine transfusions with rare blood groups by Hemchandra Pandey and challenges in transfusion management of patients with rare blood groups by Sadhana Mangwana, which underscored the logistical, ethical, and clinical complexities involved. Real case experiences emphasized the need for advance planning, donor registries, and cooperation from the national and international societies.
Discussion on rare blood group registries and international collaboration
The program concluded by an engaging video presentation on HDFN, titled Cracking the Code of HDFN: How Well Do Our IH Tests Tell the Story? by Jenny White. The session critically evaluated the benefits of structured antenatal IH testing, optimising antenatal tests, measuring antibody levels to guide clinical interventions and molecular testing and other newer advances.
Closing session highlighting advances in HDFN testing and antenatal immunohematology by Jenny White
Overall delegate feedback was highly positive. Participants rated the scientific content as relevant, current, and directly applicable to clinical practice. The balance between lectures and interactive sessions was particularly appreciated. Suggestions for future programs included longer workshop sessions and additional case-based discussions.
Speakers of the ISBT Academy Day with the Chairpersons
The ISBT Academy Session on Advances in Immunohematology successfully met its educational objectives by addressing both established and emerging challenges in Transfusion Medicine. By combining scientific updates, practical guidance, and interactive learning, the session fostered meaningful knowledge exchange and professional engagement. The enthusiastic participation and positive feedback reflect the ongoing need for focused education in immunohematology and highlight the value of ISBT Academy initiatives in advancing effective transfusion practice.
References
1. Management of Red Cell Alloimmunisation in pregnancy. American College of Obstetricians and Gynaecologists. 144(4):465-480, October 2024.
2. Bhende YM, Deshpande CK, Bhatia HM, et al. A “new” blood group character related to the ABO system. Lancet. 1952;1(6714):903–904.
3. Daniels G. Human Blood Groups. 3rd ed. Wiley-Blackwell; 2013.
4. Harmening DM. Modern Blood Banking and Transfusion Practices. 8th ed. F.A. Davis Company; 2022.
5. Garratty G. The role of immunohematology reference laboratories in resolving complex antibody problems. Immunohematology. 2014;30(1):1–7.
ISBT Academy Support
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