From Central Office
Vox Sanguinis highlights
Selection of Recently Published Articles
Tatsuki Miyamoto, Yuki Fukunaga, Ai Munakata, Katsushi Murai
Article Highlights:
- Intravenous immunoglobulins (IVIgs) contain various autoantibodies, including those against glutamic acid decarboxylase (GADAb), a valuable biomarker of type 1 diabetes mellitus.
- Titres of autoantibodies targeting GADAb vary among different IVIgs and among batches of the same product.
- GADAb originating from IVIgs can persist for a couple of months in IVIg recipients.
Akihiro Fuchizaki, Kazuta Yasui, Tomoya Hayashi, Yoshihiro Fujimura, Chiaki Oyamada, Tomoko Ohnishi-Wada, Kazuya Hosokawa, Kazushige Shimogaki, Takafumi Kimura, Fumiya Hirayama, Yoshihiro Takihara
Article Highlights:
- Prothrombin was the most important factor in haemostatic function in vitro.
- We showed that the contribution of factor X is second only to prothrombin.
- The total thrombus-formation analysis-based in vitro system can help predict haemostasis and therapeutic effects of treatments in patients with prothrombin deficiency.
Suvro Sankha Datta, Radhika Nagappan, Durba Biswas, Debapriya Basu, Kaushik Gupta, Pradip Kumar Mondal, Alexander Tuzikov, Nicolai V. Bovin, Stephen M. Henry
Article Highlights:
- TmpA–kodecytes are modified reagent red cells suitable for the detection of treponemal antibodies in routine column agglutination testing platforms.
- TmpA–kodecytes have a much higher level of agreement (97.3%) for modified T. pallidum particle agglutination-defined reactive samples, in contrast to 58.0% by rapid plasma reagin testing.
- The cost of the function-spacer-lipid-TmpA1 constructs per assay volume of TmpA–kodecytes is 1 US cent.
Albert Farrugia, Robert Perry, Françoise Rossi, Leni von Bonsdorff, Glynis Bowie, Jean-Claude Faber, Jeh-Han Omarjee, Jay Epstein, Jenny White
Article Highlights:
- The development of healthcare includes access to plasma-derived medicinal products (PDMPs) as essential therapies for a number of medical conditions.
- Strategic independence from the vagaries of the commercial market necessitates the generation of a supply of high-quality plasma from domestic donors.
- A number of models exist for the use of this plasma, depending on the state of the health system, but all of them conferring control of the supply of PDMPs on the public health service.
Ariane Lasry, Samuel Adant, Karen Farag, Celya Tidafi, Cassandra Wareham, Mandy Malick, Marie-Ève Roy-Lacroix, Pierre-Aurèle Morin, Nadine Sauvé
Article Highlights:
- The postpartum red blood cell (RBC) transfusion compliance rate in our centre approaches 80%, meeting current practice benchmarks.
- The majority of postpartum patients received multiple initial-unit RBC transfusions, while only half were treated with iron therapy in-hospital.
- Antenatal optimization of haemoglobin and ferritin stores may limit postpartum transfusions.
Zou Yu, Zheng Mao, Liao Xiuyun, Jiang Tianhua
Article Highlights:
- We report two cases of transfusion-related acute lung injury (TRALI) caused by human leucocyte antigen-II antibodies from the same donor.
- The donor's antibodies were derived from the immune stimulation of pregnancy.
- Management of blood donors with a history of multiple pregnancies is crucial.
