For the fourth episode of Talking Transfusion, hosts Allison Mo (hematologist from Melbourne, Australia) and Catherine Kimber (from the Systematic Reviews Initiative, UK) highlight one of the world’s most prevalent and serious cancers for Blood Cancer Awareness Month. Speaking with reviewers from the September Transfusion Evidence Roundup they explore recent articles on transfusion in blood cancer care, covering the latest findings, clinical challenges, and the crucial role transfusion support plays for patients living with leukemia, lymphoma, myeloma, and related conditions.